Ester C... Is it better than Vitamin C?

Ester-C was discovered back in the early 80s, when its inventor, an ever-curious doctor and scientist, set out on a quest for the first stomach-friendly Vitamin C. After much research, Ester-C would come to be known as “The Better Vitamin C” for its superior support of the immune system.

Clinical studies show Ester-C increasing vitamin C levels in white blood cells, an essential part of the immune system. Translation: Ester-C stays in your system longer than regular vitamin C, as in up to 24 hours. The naturally occurring metabolites in our formula, teeny tiny molecules that run your metabolism, are the reason why our C can last from sunrise to sunrise.

Ester-C is designed to be non-acidic, meaning that it has a neutral pH. In a recent clinical trial, people who are generally sensitive to acidic foods were given either Ester-C or ascorbic acid. Needless to say, the results prove that Ester-C is easier on the stomach.

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Clinical Study: Safety and tolerance of ester-C compared with regular ascorbic acid


The goal of this randomized, double-blind crossover clinical trial in 50 healthy volunteers sensitive to acidic foods was to evaluate whether Ester-C calcium ascorbate causes fewer epigastric adverse effects than are produced by regular ascorbic acid (AA).

Volunteers were randomly separated into 2 groups of 25. The study comprised an observation period of 9 days (phase 1 medication for 3 consecutive days, washout phase for 3 consecutive days, phase 2 medication for 3 consecutive days). Participants took 1000 mg vitamin C as Ester-C during phase 1 of the study followed by 1000 mg of vitamin C as AA during phase 2, or vice versa. During the course of the study, 3 examinations for the evaluation of epigastric adverse effects were performed (on days 0, 3, and 9). Participants used a diary to record epigastric adverse effects on a daily basis. In total, 28 (56%) of 50 participants reported 88 epigastric adverse effects of mild to moderate intensity. Of these 88 adverse effects, 33 (37.5%) occurred after intake of Ester-C and 55 (62.5%) were noted after intake of AA.

The tolerability of Ester-C was rated "very good" by 72% of participants, whereas AA was rated "very good" by only 54%. This difference is statistically significant (P<.05). Investigators concluded that Ester-C compared with AA caused significantly fewer epigastric adverse effects in participants sensitive to acidic foods and that Ester-C is much better tolerated.

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